Table 3:

Clinical studies of porcine SIS-ECM used at extracardiac sites

Study	Indication	Level of evidence	Patients	Follow-up	Outcome measure or method	Result
Boyd et al. 2010 [28]	Pericardial reconstruction	III	n = 111 (treatment) n = 111 (control)	N/A	Postoperative AF	54% reduction in relative risk (P < 0.001)
Quarti et al. 2011 [29]	Vascular repair at different sites or valve reconstruction	IV	n = 26 total	Mean 13.2 months, range (4–25 months)	Echocardiogram	No serious patch-related complications or deaths

SIS: small intestinal submucosa; ECM: extracellular matrix; AF: atrial fibrillation.