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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Pharmacogenet Genomics. 2016 Jul;26(7):324–333. doi: 10.1097/FPC.0000000000000219

Table 2. Top findings from the discovery meta-analysis of lipid response to fenofibrate in GOLDN and ACCORD.

Statistically significant findings GOLDN ACCORD Meta
SNP Chr BP A1 A2 Gene Location Trait FRQ Beta SE P FRQ Beta SE P P
rs3841260 19 19756073 A AGCC ATP13A1 UTR3 LDL-C 0.08 -0.067 0.02 1.2*10-3 0.08 -0.323 0.07 1.8*10-6 1.5*10-8
rs140229040 19 19699398 G GA PBX4 intronic LDL-C 0.07 -0.058 0.02 3.4*10-3 0.07 -0.353 0.07 3.7*10-7 1.6*10-8
rs17217098 19 19702384 A G PBX4 intronic LDL-C 0.07 -0.058 0.02 3.4*10-3 0.07 -0.352 0.07 3.8*10-7 1.6*10-8
rs150268548 19 19494483 A G MAU2/GATAD2A intergenic LDL-C 0.08 -0.050 0.02 9.2*10-3 0.08 -0.363 0.07 8.7*10-8 2.0*10-8*
rs73004967 19 19717056 G A PBX4 intronic LDL-C 0.07 -0.058 0.01 3.5*10-3 0.07 -0.342 0.07 6.4*10-7 2.5*10-8
rs73001065 19 19460541 C G MAU2 intronic LDL-C 0.07 -0.050 0.02 1.0*10-2 0.07 -0.367 0.07 1.8*10-7 4.3*10-8*
Top findings
rs140868651 19 19432290 A AG MAU2 intronic LDL-C 0.07 -0.049 0.01 1.2*10-2 0.07 -0.367 0.07 1.9*10-7 5.1*10-8*
rs57504626 19 19720399 T C PBX4 intronic LDL-C 0.09 -0.051 0.02 5.0*10-3 0.09 -0.300 0.06 1.1*10-6 5.4*10-8+
rs73004959 19 19711139 T C PBX4 intronic LDL-C 0.09 -0.051 0.02 5.0*10-3 0.09 -0.301 0.06 1.1*10-6 6.2*10-8+
rs73004962 19 19713069 T A PBX4 intronic LDL-C 0.09 -0.051 0.02 5.0*10-3 0.09 -0.297 0.06 1.3*10-6 6.7*10-8+
rs73199626 3 190888563 C T SNAR-I/OSTN intergenic TG 0.14 -0.084 0.02 4.7*10-4 0.17 -0.220 0.06 4.9*10-4 8.1*10-7
rs10990032 9 105116201 A G GRIN3A/CYL2 intergenic TG 0.06 -0.155 0.04 5.4*10-5 0.06 -0.271 0.09 4.9*10-3 1.2*10-6
rs62041965 16 79551227 A G WWOX/MAF intergenic HDL-C 0.05 0.064 0.01 1.6*10-6 0.06 0.298 0.12 0.01 2.6*10-7
rs72744354 15 51352875 A G TNFAIP8L3 intronic HDL-C 0.04 -0.066 0.01 2.6*10-6 0.04 -0.319 0.13 0.02 4.6*10-7
rs10090941 8 142370872 G C GPR20 intronic TC 0.17 0.018 0.01 1.1*10-6 0.21 0.090 0.05 0.04 1.2*10-6
rs10090104 8 142370862 A G GPR20 intronic TC 0.17 0.018 0.01 1.1*10-6 0.21 0.090 0.04 0.04 1.2*10-6

A1, allele 1; A2, allele 2 (A2 is the effect allele); BP, base-pair location; Chr, chromosome; FRQ, allele frequency for A1; Meta, meta-analysis result SE, standard error; TC, total cholesterol; SNP, single-nucleotide polymorphism. 0.01<P<0.05 for ACCORD African Americans* or Hispanics+