Table 2.

Differences in resting state connectivity in SCD patients with high and low pain hospitalizations

Seed/Network	Connected Region	Cluster Size (number of voxels)	Z scores	P- value (FWE)	MNI Coordinates
					X	Y	Z
Seed-based ROI Results
High Pain > Low Pain
Anterior cingulate cortex	Right precuneus	550	5.05	0.001	38	−66	40
Right SII	Left precuneus	166	4.14	0.002*	4	−62	42
Right IPL	Mid cingulate cortex	34	3.64	0.012*	−2	−12	42
Right posterior IC	Right SI	185	4.13	0.001*	60	−20	44
Low Pain > High Pain
Left SI	Subgenual ACC	67	3.88	0.005*	6	40	−8
Independent Component Analysis Results
High Pain > Low Pain
Default Mode	Left ACC	43	3.97	0.016*	−37	25	1
Network
Low Pain > High Pain
Salience Network	Left perigenual ACC	97	4.65	0.008*	−11	33	25

^*Small volume correction.

ACC = anterior cingulate cortex, FWE = familywise error, IC = insular cortex, IPL = inferior parietal lobule, SI = primary somatosensory cortex, SII = secondary somatosensory cortex, High Pain = high pain hospitalization group, Low Pain= low pain hospitalization group