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Recurrent splicing-factor mutations in human malignancies. Hotspot mutations in the genes coding for splicing factors U2AF1, SRSF2, and SF3B1 detected in myelodysplasia, as well as other tumor types, are indicated. In contrast, ZRSR2 mutations are distributed evenly across the gene (not shown). Domain abbreviations: (Zn) zinc finger domain, (UHM) U2AF homology motif domain, (RS) arginine/serine-rich domain, (RRM) RNA-recognition motif, (HD) heat domain.
