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. 2016 Aug 16;11(8):e0161174. doi: 10.1371/journal.pone.0161174

Table 8. Summary of relapse of inflammatory bowel disease or Clostridium difficile infection after fecal microbiota transplantation.

SAE First Author, Year (Ref.) The total number of patients Patient Preparation to FMT Infused Stools Route of Infusion Donor Relationship Number of Infusion Causality between SAEs and FMT Day post-FMT event occurred How to relieve the AE Follow-Up
Relapse of CDI Schwartz, 2013 [43] 13 CDI Antibiotics, Bowel preparation NR Colonoscopy Related NR Unrelated 12 days NR NR
Mellow, 2011 [77] 13 CDI NR 300–600 ml infusion Colonoscopy NR 1 Unrelated 7 months NR 1–10 months
Youngster, 2014 [59] 20 CDI NR 650μl*15 Capsule Unrelated 1 or 2 Unrelated NR Receiving the remaining 15 capsules 8 weeks
Wilson, 2014 [86] 45 CDI NR NR NR NR NR Unrelated NR NR 6 months
Suskind, 2015 [66] 4 UC Omeprazole, rifaximin, MiraLAX and bowel preparation Infusion of 30 mL Nasogastric tube NR 1 Unrelated 3 months Vancomycin 6 months
4 months NR
Relapse of IBD De Leon, 2013 [40] 1 UC/CDI Antibiotics 600ml infusion Colonoscopy Related 1 Probably 9 days Prednisone, mesalamine 2 weeks
Kunde, 2013 [70] 10 UC NR 70–113 g Enema Related and unrelated 5 Possibly Third week Corticosteroid enema 1 month
Kelly, 2014 [84] 80 CDI in Immunocomprom-ised Patients NR NR Colonoscopy or others NR 1 or more Possibly < 84 days NR 3–46 months
Relapse of UC, relapse of CDI Fischer, 2014 [92] 41 CDI/IBD (21 CD, 19UC, 1 indeterminate colitis) NR NR Colonoscopy or Sigmoidoscopy NR 1 or 2 Unrelated NR NR NR