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. 2016 Aug 16;11(8):e0160970. doi: 10.1371/journal.pone.0160970

Table 1. Differential response to measles virus stimulation in high vs. low antibody vaccine responders (genes with q-value <0.15).

Gene symbol FC lowa FC low log2b FC highc FC high log2d FC interactione FC int. log2f p-valueg q-value
CD93 0.06 -3.99 0.41 -1.28 6.55 2.71 <1.0E-13 <1.0E-09
IL24 0.75 -0.42 1.52 0.6 2.02 1.02 5.80E-13 4.55E-09
PID1 0.01 -6.5 0.14 -2.83 12.78 3.68 3.34E-11 1.75E-07
CCL20 1.4 0.48 0.73 -0.45 0.52 -0.93 1.85E-09 7.24E-06
ITGB8 3.73 1.9 1.71 0.77 0.46 -1.13 3.78E-08 0.0001
EHD2 0.96 -0.05 0.61 -0.72 0.63 -0.67 5.96E-07 0.0016
IL6 3.1 1.63 1.53 0.61 0.49 -1.02 8.77E-07 0.0017
GPR124 0.26 -1.93 0.7 -0.51 2.68 1.42 9.17E-07 0.0017
S1PR3 1.61 0.68 1.03 0.04 0.64 -0.64 9.69E-07 0.0017
TFPI2 1.94 0.95 0.77 -0.37 0.4 -1.33 1.89E-06 0.0027
C9orf6 0.76 -0.4 0.85 -0.24 1.12 0.17 1.91E-06 0.0027
RFX8 3.26 1.7 0.75 -0.42 0.23 -2.13 3.80E-06 0.005
VNN1 0.04 -4.56 0.34 -1.54 8.09 3.02 6.01E-06 0.007
CYP3A5 0.88 -0.19 0.49 -1.03 0.56 -0.85 6.41E-06 0.007
BCL2A1 2.12 1.08 1.04 0.06 0.49 -1.02 8.04E-06 0.008
SLC35B3 1.02 0.03 0.96 -0.06 0.93 -0.1 9.33E-06 0.009
SMPDL3A 1.27 0.34 0.51 -0.98 0.4 -1.32 1.25E-05 0.012
NAMPT 2.3 1.2 1.04 0.05 0.45 -1.15 1.90E-05 0.017
CHST7 3.42 1.78 2.08 1.05 0.61 -0.72 2.35E-05 0.019
LIF 5.23 2.39 1.37 0.45 0.26 -1.93 3.41E-05 0.027
FLT1 1.03 0.04 0.64 -0.65 0.62 -0.69 3.73E-05 0.028
HTR7 0.14 -2.88 0.36 -1.48 2.64 1.4 4.09E-05 0.029
VEGFA 0.82 -0.29 0.46 -1.12 0.56 -0.83 4.91E-05 0.033
MAP1LC3A 1.99 0.99 1.12 0.16 0.56 -0.83 5.52E-05 0.036
FAM149B1 1.11 0.15 1.03 0.05 0.93 -0.1 6.13E-05 0.038
AK4 6.65 2.73 1.98 0.98 0.3 -1.75 6.24E-05 0.038
FPR2 1.96 0.97 0.37 -1.43 0.19 -2.4 8.03E-05 0.047
SIGLEC15 0.14 -2.87 0.83 -0.27 6.09 2.61 9.11E-05 0.051
MSC 8.36 3.06 3.18 1.67 0.38 -1.39 0.0001 0.054
HES1 1.34 0.42 0.82 -0.29 0.61 -0.72 0.0001 0.054
SGCD 0.33 -1.62 0.46 -1.12 1.42 0.5 0.0001 0.06
CYP1A1 4.6 2.2 1.65 0.72 0.36 -1.48 0.0001 0.066
MET 2.41 1.27 1 0 0.42 -1.27 0.0001 0.066
IL36RN 78.19 6.29 12.19 3.61 0.16 -2.68 0.0001 0.066
LOC154092 1.13 0.18 0.52 -0.95 0.46 -1.13 0.0001 0.066
G0S2 0.29 -1.77 1.01 0.01 3.44 1.78 0.0002 0.078
OR52N4 2.56 1.36 1.71 0.77 0.67 -0.58 0.0002 0.081
TRPA1 2.22 1.15 1.14 0.19 0.52 -0.96 0.0002 0.086
LAMB3 0.28 -1.81 0.68 -0.56 2.38 1.25 0.0002 0.092
ST20 0.92 -0.11 0.71 -0.49 0.77 -0.38 0.0003 0.101
STK31 0.95 -0.08 0.71 -0.49 0.75 -0.42 0.0003 0.101
CCL24 0.02 -5.70 0.07 -3.93 3.40 1.76 0.0003 0.109
CD33 0.07 -3.93 0.13 -2.97 1.95 0.96 0.0003 0.109
IL10 0.61 -0.72 1.69 0.76 2.78 1.48 0.0003 0.110
LZTS1 1.12 0.17 0.86 -0.22 0.76 -0.39 0.0003 0.113
ITGB3 1.60 0.68 1.07 0.10 0.67 -0.57 0.0004 0.120
DLEU2 1.74 0.80 1.44 0.52 0.82 -0.28 0.0004 0.134
STX1A 0.79 -0.34 0.52 -0.93 0.66 -0.59 0.0004 0.135
LOC730227 1.11 0.15 0.77 -0.37 0.70 -0.52 0.0005 0.146
CXCL2 0.61 -0.71 1.24 0.31 2.04 1.03 0.0005 0.146

aFold change gene expression for the virus-stimulated PBMCs (low responders) relative to the unstimulated PBMCs (low responders}

bLog2 of the fold change, described in (a).

cFold change gene expression for the virus-stimulated PBMCs (high responders) relative to the unstimulated PBMCs (high responders}.

dLog2 of the fold change, described in (c).

eInteraction fold change is the ratio of the fold change for the stimulated (high responders) relative to unstimulated (high responders) (c) relative to the stimulated (low responders) relative to the unstimulated (low responders) (a)

fLog2 fold change for the interaction (e).

gP-value associated with the test for a gene expression difference in high responders (response to viral stimulation), relative the response of low responders (response to viral stimulation). For CADM1, p-value = 0.0008 and q-value = 0.203