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. 2016 May 31;8(3):83–95. doi: 10.1080/19382014.2016.1182276

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Transcriptomic comparison of in vitro-differentiated versus in vivo-matured human embryonic stem cells and primary human adult islets. (A) Heatmap showing the Euclidean distances between samples generated in this study and similar in vitro-differentiated and in vivo-matured human embryonic stem cells²⁵ as calculated from the voom-transformed expression values. (B) Plot of the first 2 principal components derived from the normalized expression profiles of iPSC in vitro-differentiated and hESC in vivo-matured cells²⁵, as well as adult islets and FACS-enriched β-cell fractions⁵⁷. ES = embryonic stem cells; iPSC = induced pluripotent stem cells; DE = definitive endoderm; GT = primitive gut tube; PF = posterior foregut; PE = pancreatic endoderm; EN = endocrine pancreas-like cells.