Table 1.
Karyotypes are stable in select BubR1 mutant overexpressing MEFs. Karyotype analysis of passage 5 MEFs of indicated genotype. n ≥ 3 lines, 50 cells per line. Data are mean ± s.d. WT, wild-type. FL, full-length. (See associated Table 1— source data 1).
DOI: http://dx.doi.org/10.7554/eLife.16620.005
Table 1—source data 1. Source file for MEF aneuploidy rate data.
elife-16620-table1-data1.xlsx (11KB, xlsx)
DOI: 10.7554/eLife.16620.006
| Mitotic MEF genotype (n) |
Mitotic figures | Aneuploid figures % (s.d) |
Karyotype with indicated chromosome number | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | |||
| WT (5) | 250 | 9 (6) | 1 | 1 | 0 | 5 | 227 | 9 | 7 | 0 | 0 |
| FL-Bub1b (3) | 150 | 10 (3) | 0 | 0 | 1 | 2 | 135 | 7 | 5 | 0 | 0 |
| Bub1bΔI (3) | 150 | 8 (3) | 0 | 0 | 1 | 2 | 138 | 9 | 0 | 0 | 0 |
| Bub1bΔN (5) | 250 | 18 (6)* | 0 | 0 | 2 | 15 | 204 | 23 | 6 | 0 | 0 |
| Bub1bN (3) | 150 | 6 (2) | 0 | 0 | 1 | 3 | 141 | 4 | 1 | 0 | 0 |
*p<0.05.