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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Curr Opin Neurobiol. 2016 May 3;39:93–100. doi: 10.1016/j.conb.2016.04.013

Figure 1. Recent findings underlying oligodendrocyte precursor cell (OPCs) migration, motility, and distribution.

Figure 1

a) Embryonic migration along blood vessels is mediated by OPC-endothelial interactions via Wnt -Cxcr4 signaling [6]. b) The modulation of Rho GTPases by chondroitin proteoglycan, NG2, regulates OPC polarity and directional migration [8]. c) Local proliferation (yellow arrowheads) regulates OPC density in response to OPC turnover (differentiating OPC, purple) [11]; recent work indicates netrin-1 signaling may underlie this spatial homeostasis [13].