Table 4.
Summary of known and inferred protein-protein interactions between zebrafish esr1 and successfully mapped zebrafish orthologs of putative co-regulatory proteins identified in the 17β-estradiol (E2) exposed group in our study as determined by STRING analysis.
| Human gene symbol | Zebrafish gene symbol | Protein name | Human interaction | Zebrafish interaction |
|---|---|---|---|---|
| ESR1 | esr1 | Estrogen receptor | – | – |
| ACYP1 | acyp1 | Acylphosphatase-1 | ||
| ARF6 | arf6a | ADP-ribosylation factor 6 | ‡ | ‡ |
| C2CD3 | c2cd3 | C2 domain-containing protein 3 | ||
| CBX3 | cbx3a | Chromobox protein homolog 3 | ||
| CCDC47 | ccdc47 | Coiled-coil domain-containing protein 47 | ||
| CDC14A | cdc14aa | Dual specificity protein phosphatase CDC14A | ||
| COG3 | cog3 | Conserved oligomeric Golgi complex subunit 3 | ||
| CTNNB1 | ctnnb1 | Catenin beta-1 | † | |
| CYC1 | cyc1 | Cytochrome c1, heme protein, mitochondrial | ‡ | |
| DNAJA3 | dnaja3b | DnaJ homolog subfamily A member 3, mitochondrial | ‡ | |
| DYSF | dysf | Dysferlin | ||
| EFHD2 | efhd2 | EF-hand domain-containing protein D2 | ||
| EFR3A | efr3a | Protein EFR3 homolog A | ||
| EIF2S1 | eif2s1a | Eukaryotic translation initiation factor 2 subunit 1 | ‡ | ‡ |
| ENAH | enah | Protein enabled homolog | ‡ | ‡ |
| FLNC | flnca | Filamin-C | ‡ | ‡ |
| GIPC1 | gipc1 | PDZ domain-containing protein GIPC1 | ||
| GLUD1 | glud1a | Glutamate dehydrogenase 1, mitochondrial | ‡ | |
| GNA12 | gna12a | Guanine nucleotide-binding protein subunit alpha-12 | ‡ | † |
| GNAQ | gnaq | Guanine nucleotide-binding protein G(q) subunit alpha | † | † |
| GNB3 | gnb3a | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | ‡ | ‡ |
| GPC4 | gpc4 | Glypican-4 | ‡ | |
| HN1L | hn1l | Hematological and neurological expressed 1-like protein | ||
| HSD17B10 | hsd17b10 | 3-hydroxyacyl-CoA dehydrogenase type-2 | ||
| IDH3A | idh3a | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | ||
| INF2 | inf2 | Inverted formin-2 | ||
| KARS | kars | Lysine–tRNA ligase | ‡ | |
| KHDRBS2 | khdrbs2 | KH domain-containing, RNA-binding, signal transduction-associated protein 2 | ‡ | |
| LMNB2 | lmnb2 | Lamin-B2 | ‡ | |
| LRRFIP1 | lrrfip1a | Leucine-rich repeat flightless-interacting protein 1 | ‡ | |
| MAGOH | magoh | Protein mago nashi homolog | ‡ | |
| N4BP3 | n4bp1 | NEDD4-binding protein 3 | ||
| NDUFS3 | ndufs3 | NADH dehydrogenase [ubiquinone] iron–sulfur protein 3, mitochondrial | ||
| NTPCR | ntpcr | Cancer-related nucleoside-triphosphatase | ||
| P2RX4 | p2rx4a | P2X purinoceptor 4 | ||
| PABPN1 | pabpn1l | Polyadenylate-binding protein 2 | ||
| PAPSS1 | papss1 | Bifunctional 3′-phosphoadenosine 5′-phosphosulfate synthase 1 | ||
| PDK3 | pdk3a | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial | ||
| PSME3 | psme3 | Proteasome activator complex subunit 3 | † | ‡ |
| PUF60 | puf60a | Poly(U)-binding-splicing factor PUF60 | ‡ | |
| RFFL | rffl | E3 ubiquitin-protein ligase rififylin | ||
| SF1 | sf1 | Splicing factor 1 | ||
| SLC25A1 | slc25a1a | Tricarboxylate transport protein, mitochondrial | ||
| SMC4 | smc4 | Structural maintenance of chromosomes protein 4 | ||
| SMPDL3B | smpdl3b | Acid sphingomyelinase-like phosphodiesterase 3b | ||
| SMYD1 | smyd1a | SET and MYND domain-containing protein 1 | ||
| SNRPF | snrpf | Small nuclear ribonucleoprotein F | ‡ | |
| SORBS1 | sorbs1 | Sorbin and SH3 domain-containing protein 1 | ‡ | |
| SPAG1 | spag1a | Sperm-associated antigen 1 | ||
| SPTB | sptb | Spectrin beta chain, erythrocytic | ‡ | |
| SRPRB | srprb | Signal recognition particle receptor subunit beta | ‡ | |
| TMEM205 | tmem205 | Transmembrane protein 205 | ||
| TOMM70A | tomm70a | Mitochondrial import receptor subunit TOM70 | ||
| TRIM2 | trim2a | Tripartite motif-containing protein 2 | ||
| TSFM | tsfm | Elongation factor Ts, mitochondrial | ‡ | |
| TUBB2A | tubb2 | Tubulin beta-2 A chain | † | |
| VIM | vim | Vimentin | ‡ | |
| ATP4A | atp1a1a.4 | Potassium-transporting ATPase alpha chain 1 | ‡ | |
| HIST1H1D | histh1l | Histone H1.3 | ‡ | |
| PGAM4 | pgam1a | Probable phosphoglycerate mutase 4 | ||
| PLEKHG3 | plekhg3 | Pleckstrin homology domain-containing family G member 3 | ‡ | |
| RBBP7 | rbb4l | Histone-binding protein RBBP7 | † | |
| THEM6 | them6 | Protein THEM6 |
†
Proteins sharing primary relationship with zebrafish esr1 are denoted
‡
proteins sharing secondary relationships with esr1 are denoted