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. Author manuscript; available in PMC: 2017 Aug 15.
Published in final edited form as: Clin Cancer Res. 2016 Mar 15;22(16):4105–4118. doi: 10.1158/1078-0432.CCR-15-2624

Figure 2. EC-8042 is a less toxic mithramycin analog.

Figure 2

EC-8042 had a less pronounced effect on A, liver enzymes; B, liver synthetic function; and C, hematopoiesis in rats after doses of 0.8 mg/kg IV of mithramycin relative to (4 mg/kg) or (8 mg/kg) of EC-8042. D EC-8042 exhibited a higher Cmax and delayed clearance relative to mithramycin (MMA) in mice.