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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Neurobiol Learn Mem. 2016 Jun 2;133:39–52. doi: 10.1016/j.nlm.2016.06.001

Figure 4.

Figure 4

Neurobiological processes via which NBM corticopetal cholinergic neurons modulate emotional memory. A) Neural circuits. NBM cholinergic neurons are in green, LC neurons are in red, central amygdala (CeA) neurons are in yellow, and NBM GABAergic neurons are in purple. Components of the neural circuit that need verification are shown in dashed lines. B) Electrophysiological mechanisms. NBM corticoptal cholinergic input to the PFC increases the slow-wave components (1-4Hz) of the PFC local field potential (LFP) and may disrupt decreases in slow wave PFC LFP during fear conditioning. These effects may mediate the disruptive effect NBM corticopetal cholinergic lesions have on fear memory in the conditioned suppression paradigm. preFC – pre fear conditioning.