. Author manuscript; available in PMC: 2017 Aug 15.

Published in final edited form as: Clin Cancer Res. 2016 Mar 22;22(16):4206–4214. doi: 10.1158/1078-0432.CCR-15-2793

Table 1. Summary statistics of the treatment response data analysis.

The table displays statistics on the individual patient model fitting as well as whole cohort model fitting for the cohorts for the three trials during treatment. See SI, “Treatment phase model fitting”, for details.

	VISTA MP cohort during treatment (255 patients)		VISTA VMP cohort during treatment (249 patients)
	2-phasic exponential model	Exponential model	2-phasic exponential model	Exponential model
Min^* of $R_{i}^{2}$	0.089	0	0.174	0.002
1^st Quartile^* of $R_{i}^{2}$	0.678	0.327	0.874	0.374
Median^* of $R_{i}^{2}$	0.865	0.629	0.929	0.645
Mean^* of $R_{i}^{2}$	0.787	0.572	0.889	0.577
3^rd Quartile^* of $R_{i}^{2}$	0.938	0.847	0.962	0.813
Max^* of $R_{i}^{2}$	0.999	0.980	1	0.955
^**Final R²	0.902	0.706	0.910	0.642
^***Sum of BICs	−1096.8	−978.9	−773.1	−480.5

	MMY-2001 VMP cohort during treatment (40 patients)		MMY-2001 SVMP cohort during treatment (38 patients)
	2-phasic exponential model	Exponential model	2-phasic exponential model	Exponential model
Min^* of $R_{i}^{2}$	0.684	0.007	0.187	0.003
1^st Quartile^* of $R_{i}^{2}$	0.872	0.444	0.876	0.250
Median^* of $R_{i}^{2}$	0.926	0.630	0.948	0.399
Mean^* of $R_{i}^{2}$	0.912	0.573	0.883	0.473
3^rd Quartile^* of $R_{i}^{2}$	0.968	0.731	0.968	0.773
Max^* of $R_{i}^{2}$	0.999	0.938	1	0.950
^**Final R²	0.929	0.640	0.934	0.471
^***Sum of BICs	−313.9	−241.5	−309.5	−214.8

	APEX DEX cohort during treatment (143 patients)		APEX VEL cohort during treatment (168 patients)
	2-phasic exponential model	Exponential model	2-phasic exponential model	Exponential model
Min^* of $R_{i}^{2}$	0.054	0.000	0.228	0.000
1^st Quartile^* of $R_{i}^{2}$	0.716	0.105	0.828	0.195
Median^* of $R_{i}^{2}$	0.846	0.370	0.937	0.529
Mean^* of $R_{i}^{2}$	0.799	0.404	0.873	0.498
3^rd Quartile^* of $R_{i}^{2}$	0.944	0.684	0.983	0.777
Max^* of $R_{i}^{2}$	1.000	0.964	1.000	0.996
^**Final R²	0.830	0.496	0.898	0.580
^***Sum of BICs	−1402.5	−1201.4	−1729.7	−1376.1

the Minimum/1^st Quartile/Median/Mean/3^rd Quartile/Maximum of the $R_{i}^{2}$ , i = 1, …, N, calculated from the corresponding fitted model for each individual patient, where N is the total number of patients and $R_{i}^{2}$ = 1 - SSE_i / SST_i;

^**

Final R², calculated as 1 - Σ SSE_i / Σ SST_i, evaluates the overall fit of the corresponding model to the whole time series data with all patients for each cohort;

^***

Sum of BICs is the sum of BICs over all subjects for each cohort.