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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Reprod Toxicol. 2016 May 7;63:32–48. doi: 10.1016/j.reprotox.2016.03.042

Figure 3.

Figure 3

MEHP treatment impairs neural tube closure in WEC. An unusually high number of open neural tubes were observed in the MEHP-treated groups after 24 h treatment. Some of those malformations are shown above. Overall, with increased concentration of MEHP in the culture media, there is a reduction of neural tube scores. The highest possible total neural tube score attainable is 20, and scores are reduced by characteristics such as an open neural tube, necrotic debris present in the neural tube, and hypoplastic tissues around the brain regions. *** indicates a very significant change (p<0.001) in the MEHP group from the control at this dose.