Table 2.

EMB and VYS pathways with significantly altered gene expression by 6h MEHP treatment in WEC. Significantly enriched KEGG pathways in the EMB (shown left) and the VYS (shown right) include many metabolic pathways, including severaldependent upon the redox environment, and pathways associated with the nervous system.

Pathways significantly enriched in EMB tissue	Odds Ratio	P-value	Pathways significantly enriched in VYS tissue	Odds Ratio	P-value
Oxidative phosphorylation	4.136	0.001	Oxidative phosphorylation	8.109	0.000
Alanine, aspartate and glutamate metabolism	8.517	0.002	Parkinson’s disease	7.795	0.000
Retinol metabolism	5.637	0.005	Glutathione metabolism	13.522	0.000
Phagosome	3.060	0.008	Alzheimer’s disease	5.166	0.000
Proteasome	5.231	0.010	Aminoacyl-tRNA biosynthesis	11.307	0.000
Rheumatoid arthritis	3.816	0.011	Histidine metabolism	11.235	0.002
Collecting duct acid secretion	6.880	0.012	N-Glycan biosynthesis	8.051	0.002
Purine metabolism	2.679	0.014	Antigen processing and presentation	7.024	0.003
Arginine and proline metabolism	4.135	0.023	Drug metabolism - cytochrome P450	6.644	0.004
Vasopressin-regulated water reabsorption	4.610	0.024	Selenocompound metabolism	14.129	0.006
Starch and sucrose metabolism	4.713	0.028	Huntington’s disease	3.321	0.007
Histidine metabolism	5.117	0.040	Alanine, aspartate and glutamate metabolism	8.852	0.007
Parkinson’s disease	2.633	0.047	Arginine and proline metabolism	5.335	0.015
			Ribosome biogenesis in eukaryotes	4.276	0.022
			Complement and coagulation cascades	3.972	0.039