Table 3.
Solute carrier (SLC) family gene expression is significantly impacted by 6h MEHP treatment in WEC. The mitochondrial transport family (SLC25) represents the most significantly altered family of transporters, crucial for the catabolic processes of the cell.
| # genes sig. changed | ||||
|---|---|---|---|---|
| SLC family | Function | EMB | VYS | TOTAL |
| 1 | glial high affinity glutamate/neutral amino acid transporter | 1 | 2 | 3 |
| 4 | bicarbonate transporters | 6 | 2 | 8 |
| 5 | inositol/sodium-dependent glucose transporters | 2 | 1 | 3 |
| 6 | neurotransmitter transporters | 3 | 0 | 3 |
| 7 | cationic/L-type amino acid transporters | 3 | 2 | 5 |
| 8 | sodium/calcium exchangers | 1 | 1 | 2 |
| 9 | sodium/hydrogen exchangers | 3 | 3 | 6 |
| 10 | sodium/bile salt exchangers | 0 | 1 | 1 |
| 11 | proton-coupled divalent metal ion transporters | 1 | 0 | 1 |
| 12 | electroneutral cation-coupled chloride cotransporters | 2 | 1 | 3 |
| 13 | sodium sulphate/carboxylate exchangers | 0 | 1 | 1 |
| 16 | monocarboxylic acid transporters | 6 | 2 | 8 |
| 17 | phosphate/organic anion transporters | 2 | 1 | 3 |
| 19 | folate/thiamine transporters | 1 | 1 | 2 |
| 21 | organic anion transporters | 4 | 3 | 7 |
| 22 | organic cation/anion transporters | 4 | 0 | 4 |
| 23 | ascorbate/nucleobase transporters | 1 | 1 | 2 |
| 24 | sodium/potassium/calcium exchangers | 1 | 0 | 1 |
| 25 | mitochondrial transporters | 9 | 6 | 15 |
| 26 | sulfate/anion transporters | 2 | 2 | 4 |
| 29 | nucleoside transporters | 1 | 0 | 1 |
| 30 | zinc transporters | 2 | 2 | 4 |
| 31 | copper transporters | 1 | 0 | 1 |
| 33 | acetyl-CoA transporters | 0 | 1 | 1 |
| 35 | nucleotide sugar transporters | 8 | 1 | 9 |
| 36 | proton-coupled amino acid transporters | 0 | 1 | 1 |
| 37 | sugar phosphate exchangers | 1 | 0 | 1 |
| 38 | sodium-amino acid cotransporters | 1 | 0 | 1 |
| 39 | zinc/metal ion transporters | 1 | 3 | 4 |
| 44 | choline transporter-like family | 1 | 2 | 3 |
| 45 | putative sugar transporters | 2 | 1 | 3 |
| 46 | folate transporters | 1 | 1 | 2 |