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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Crit Care Med. 2016 Sep;44(9):e809–e817. doi: 10.1097/CCM.0000000000001739

Figure 1. Associations between Markers of Endothelial Activation and Blood-Brain Barrier Injury and Delirium/Coma-Free Days.

Figure 1

Higher PAI-1 (P = 0.002), E-selectin (P = 0.02), and S100B (P < 0.001) plasma concentrations were associated with fewer delirium/coma-free days after adjusting for age, Charlson comorbidity index (45), modified SOFA score (27), and severe sepsis. The solid lines demonstrate the point estimates of the associations between PAI-1, E-selectin, and Ang-2 as markers of endothelial activation and S100B as a marker of blood-brain barrier injury versus delirium/coma-free days, with the gray ribbons indicating the 95% confidence intervals. Abbreviations: Ang-2, angiopoietin-2; PAI-1, plasminogen activator inhibitor-1