Table 3.

Comparison of clinical outcomes by diagnostic criteria

	P16 Positive N (%)	P16 Negative N (%)	P16 Positive 2-/5- Year DFS, 2-/5- Year OS	P16 negative 2-/5- Year DFS, 2-/5- Year OS	Statistical significance (Log-Rank)
Lewis et al criteria: Positive when >75% or >50% positive AND > 25% confluence	48 (59%)	33 (41%)	85%/ 76%, 94%/ 80%	55%/ 39%, 66%/ 39%	p < 0.001 p < 0.001
Modified Criteria: Positive when >75% or 26-75% positive AND >75% confluence	51 (63%)	30 (37%)	82% 77%, 92%/ 76%	56%/ 34%, 66%/ 41%	p < 0.001 p < 0.001

DFS, disease free survival; OS, overall survival