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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2016 Feb 16;174(1):93–112. doi: 10.1002/ajmg.b.32429

FIG. 1.

FIG. 1

A: Adult neurogenesis occurs in two regions: the subgranular zone (SGZ) and the subventricular zone (SVZ). B: In the SVZ, neural progenitor cells (type B cells) give rise to type C cells, which differentiate to neuroblasts (type A cells). Type A cells migrate via the rostral migratory stream (RMS) and differentiate into neurons in the olfactory bulb (OB). Neuroblasts migrate via the RMS to the olfactory bulb and generate new neurons. C: In the SGZ, glial-like radial stem cells known as Type-I cells express glial fibrillary acidic protein (GFAP) and nestin. They divide to produce intermediate stage progenitors (Type-II cells), which then undergo further rounds of cell division to generate neuroblasts and post-mitotic immature granule neurons. Type II cells express Sox2, while neuroblast and immature neurons express doublecortin (DCX), PSA-NCAM, and calretinin. Mature neurons are defined by expression of NeuN. [Color figure can be seen in the online version of this article, available at http://wileyonlinelibrary.com/journal/ajmgb].