Table 1.

Plasma and urinary metabolites found significantly changed (q<0.05) in comparisons assessing effect of iAs treatment in male and female wild-type (WT) and As3mt-knockout (KO) mice. Fold change indicates difference from the second group in the comparison.

	Urine			Plasma
Comparison	Metabolite	q-value	Fold Change	Metabolite	q-value	Fold change
KO, female 1 ppm vs 0 ppm	C18:1	0.01	−1.50	none
	C14	0.02	−1.36
	SM (OH) C14:1	0.01	1.79
KO, male 1 ppm vs 0 ppm	none			none
WT, female 1 ppm vs 0 ppm	none			none
WT, male 1 ppm vs 0 ppm	none			none

^*CX:Z, acyl-carnitine; SM(OH)CX:Z, sphingomyolipid (X indicates number of carbons of the fatty acid tail and Z indicates total number of double bonds).