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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Gut. 2016 Feb 16;66(7):1197–1207. doi: 10.1136/gutjnl-2015-310341

Figure 2. Pharmacological inhibition of autophagy promotes eosinophil infiltration and basal cell hyperplasia in a murine EoE model.

Figure 2

BALB/c mice were treated with MC903 and OVA for 32 days. From days 18–32, HCQ (60 mg/kg) (n=4) or vehicle (PBS) (n=7) were delivered via daily i.p. injection. (A) Oesophageal tissues were evaluated by H&E (arrows, eosinophils) as well as IHC for p63 (basal cells) and cleaved LC3 (autophagy). Scale bars, 50 µm. (B and C) Eos and p63-positive basal cells were determined. *p<0.05 vs. MC903/OVA (+) HCQ (−).