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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Gut. 2016 Feb 16;66(7):1197–1207. doi: 10.1136/gutjnl-2015-310341

Figure 9. Model depicting the dynamic interplay between autophagy and ROS in the context of EoE inflammation.

Figure 9

(A) EoE-relevant cytokines promote ROS accumulation to activate autophagy which subsequently suppresses ROS. (B) The balance between autophagy and ROS may be a critical determinant of oesophageal keratinocyte cell fate. In EoE, the inflammatory milieu promotes BCH as squamous cell differentiation is impaired. Under these conditions, autophagy may act as a homeostatic mechanism to maintain cellular redox balance and prevent excessive basal cell proliferation as well as cell death.