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. Author manuscript; available in PMC: 2016 Aug 16.
Published in final edited form as: RNA Dis. 2016 Jun 6;3(2):e1336. doi: 10.14800/rd.1336

Figure 3. DEAH-RHA proteins in highly divergent lineages.

Figure 3

The graphical representations are at scale. Predictions from NCBI’s CD-searches gave the domain annotations in the human genes (DHX prefix), in their yeast homologs (in brackets), and in E. coli Hpr genes. REH2 was described above. Another study identified the N-terminal dsRBD elements in DHX29 in a structure search (*) [51]. DHX30 has an N-terminal dsRBD annotated in UniProtKB [52] that was detected with the Phyre2 server but not with a CD-search analysis. An unidentified N-terminal RNA-binding domain in DHX36 was determined experimentally (#) [22]. Other conserved domains that flank the DEAH-RHA defining features are: RWD (pfam05773), UBA_DHX57 (cd14317), UBA_YLR419W_like (cd14271), ZnF_C3H1 (smart05773), S1_DHX8_helicase (cd05684), and DUF3418 (pfam11898). Protein sizes and the DEAH family defining residues in mot II are indicated as in Fig. 2. Some of the proteins listed here have additional conserved domains or sequence features that were not detected in the CD-searches but that have been identified through functional or sequence analyses. For example, RHA has a domain for binding to RNA polymerase II between dsRBD2 and RecA1. Also, the C-terminus of RHA includes two RGG-boxes and nuclear localization/export signals [24].