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. 2016 Aug 15;214(4):459–474. doi: 10.1083/jcb.201601014

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© 2016 McLaughlin et al.

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Figure 1. — Toll-6 and dSARM promote FoxO nuclear localization in the CNS. (A–D) Representative z projections of three segments of L3 VNCs of the indicated genotypes labeled with anti-FoxO. Bar, 20 µm. (insets) High magnification z projections of Toll-6^EX13 and dSARM⁴⁶²¹ L3 VNCs. Arrows indicate cytoplasmic FoxO staining. Bar, 10 µm. (E) Quantification of total number of cells with nuclear FoxO. Wild type (OregonR): 109.2 ± 5.9 (n = 11 VNCs); Toll-6^EX13: 70.8 ± 8.7 (n = 9 VNCs); Toll-7^g1-1: 99.4 ± 5.0 (n = 10 VNCs); and dSARM⁴⁶²¹: 55.7 ± 3.1 (n = 6 VNCs). Anterior is up. Error bars are mean ± SEM. n.s., not significantly different. *, P < 0.05; ***, P < 0.001.