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. 2016 Aug 15;214(4):459–474. doi: 10.1083/jcb.201601014

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© 2016 McLaughlin et al.

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Figure 3. — Toll-6, dSARM, and FoxO regulate presynaptic MT stability. (A–D) Representative confocal projections of Futsch-positive MT loops at NMJ6/7 of indicated genotypes. Bar, 10 µm. (E) Quantification of Futsch-positive MT loops at NMJ6/7 in segment A2. Wild type: 12.6 ± 0.5 (n = 22); foxO^Δ94: 18.7 ± 1.0 (n = 19); Toll-6^EX13: 17.6 ± 1.1 (n = 34); Toll-6^EX13, foxO^Δ94: 19.1 ± 0.9 (n = 16); and dSARM⁴⁶²¹: 19.5 ± 1.0 (n = 20). (F–I) Representative confocal projections of Ac-Tub and HRP-labeled NMJ4s of indicated genotypes. Bar, 5 µm. (J) Quantification of proportion of boutons at NMJ4 with expanded Ac-Tub labeling. Wild type (OregonR): 0.06 ± 0.03 (n = 17); foxO^Δ94: 0.33 ± 0.04 (n = 9); Toll-6^EX13: 0.33 ± 0.02 (n = 10); Toll-6^EX13, foxO^Δ94: 0.26 ± 0.04 (n = 20); and dSARM⁴⁶²¹: 0.23 ± 0.03 (n = 19). Error bars are mean ± SEM. n.s., not significantly different. **, P < 0.01; ***, P < 0.001.