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. 2016 Aug 15;214(4):459–474. doi: 10.1083/jcb.201601014

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© 2016 McLaughlin et al.

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Figure 7. — Excessive MT stability impairs rapid structural plasticity in Toll-6 pathway mutants. (A) Quantification of nascent boutons at NMJ6/7 treated with VBL or 0.2% DMSO before high K⁺ stimulation. Wild type_DMSO: 7.7 ± 0.7 (n = 6); wild type_VBL: 7.3 ± 0.5 (n = 27); foxO^Δ94_DMSO: 3.6 ± 0.3 (n = 13); foxO^Δ94_VBL: 6.8 ± 0.8 (n = 18); Toll-6^EX13_DMSO: 2.9 ± 0.7 (n = 15); Toll-6^EX13_VBL: 9.4 ± 1.4 (n = 18); Toll-6^EX13, foxO^Δ94_DMSO: 2.8 ± 0.3 (n = 16); Toll-6^EX13, foxO^Δ94_VBL: 7.0 ± 0.8 (n = 15); dSARM⁴⁶²¹_DMSO: 3.3 ± 0.3 (n = 6); and dSARM⁴⁶²¹_VBL: 6.3 ± 0.7 (n = 11). Wild type is OregonR. (B) Quantification of nascent boutons at NMJ6/7 treated with VBL or 0.2% DMSO before high K⁺ stimulation. Control_DMSO: 7.5 ± 1.2 (n = 21); control_VBL: 8.1 ± 0.8 (n = 16); D42>dcr-2; foxO RNAi_DMSO: 3.8 ± 0.9 (n = 18); D42>dcr-2; foxO RNAi_VBL: 9.0 ± 1.0 (n = 13); D42>dcr-2; Toll-6 RNAi^#1_DMSO: 4.3 ± 1.0 (n = 12); D42>dcr-2; Toll-6 RNAi^#¹_VBL: 7.8 ± 1.0 (n = 19); D42>dcr-2; dSARM RNAi^#¹_DMSO: 2.7 ± 0.5 (n = 9); and D42>dcr-2; dSARM RNAi ^#1_VBL: 9.0 ± 1.0 (n = 13). Control is D42>dcr-2. (C) Quantification of nascent boutons at NMJ6/7 treated with VBL or 0.2% DMSO before high K⁺ stimulation. Control_DMSO: 7.9 ± 1.3 (n = 11); control_VBL: 7.3 ± 1.1 (n = 16); OK6>Pav^#1_DMSO: 2.8 ± 0.9 (n = 10); OK6>Pav^#1_VBL: 15.4 ± 2.8 (n = 11); OK6>Pav^#2_DMSO: 3.8 ± 1.0 (n = 19); and OK6>Pav^#2_VBL: 9.5 ± 1.4 (n = 11). Control is OK6Gal4/+. Error bars are mean ± SEM. n.s., not significantly different. *, P < 0.05, **, P < 0.01; ***, P < 0.001.