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. 2016 Aug 15;214(4):363–365. doi: 10.1083/jcb.201607117

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© 2016 Mokranjac

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Figure 1. — A disulfide bond in Tim17. In this issue, Ramesh et al. (2016) identify a disulfide bond in yeast Tim17 that likely plays a structural role in the TIM23 complex (left). In an independent study, Wrobel et al. (2016) demonstrate that this disulfide bond is not only present in yeast, but also in human Tim17B (right). Humans have an additional Tim17 protein, Tim17A, which is degraded under stress conditions. Could the degradation of Tim17A be regulated via the redox state of its cysteine residues? IMS, intermembrane space; IM, inner membrane.