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Virus replication cycle after virus infection into a cell. (I) During virus entry, M2 proton channel shunts H+ from the acidic endosome to the virion interior, leading to membrane fusion and release of the genome. (II) During virus exit, M2 shunts H+ from trans-Golgi network to the cytoplasm, preventing premature conformational changes in the viral hemagglutinin (HA).
