Figure 4.

The effects of PI3-kinase and Akt inhibitors on ethanol-induced suppression of γ oscillations. (A) Example of the effect of ethanol on γ power in the presence of the PI3 kinase inhibitor wortmannin (200 nM). Details as in Figure 2A. (B) γ power as % of baseline for wortmannin (Wort), 50 mM ethanol (n = 16) and 100 mM ethanol (n = 11) Details as in Figure 2B. ^*P < 0.05; ^**P < 0.01. (C) Example of the effect of ethanol on γ power in the presence of the Akt inhibitor TCBN (5 μM). Details as in Figure 2A. (D) γ power as % of baseline for TCBN, 50 mM ethanol (n = 9) and 100 mM ethanol (n = 9). Details as in Figure 2B. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001.