FIGURE 1.

Course of an MHV68 infection in mice. Acute lytic replication occurs in the lung (intranasal infection) or in the spleen (intraperitoneal infection). Ongoing replication is cleared typically by 12 days. The peak of latency is measured around 16 days post-infection in secondary lymphoid tissues such as the spleen. Maintenance of latency is typically evaluated 42 days post-infection. B cells are the predominant latency reservoir, followed by macrophages, dendritic cells, and endothelial cells. Lymphomas arise at late stages in immunocompromised animals.