Table 8.
The brain phenotype of untreated homosexual male-to-female transsexuals from studies of cortical thickness and white matter microstructure
| Normative sex differences (M vs. F) | Phenotype | Hemisphere | |
|---|---|---|---|
| Cerebral compartments | M > F | Masculine | |
| Gray matter | M > F | Masculine | |
| White matter | M > F | Masculine | |
| Intracranial volume | M > F | Masculine | |
| CSF | |||
| Cortical thickness | F > M | Feminine | Right |
| Global | F > M | Feminine | Right |
| Orbitofrontal | F > M | Feminine | Right |
| Insular | F > M | Feminine | Right |
| Cuneus | |||
| White matter microstructure | |||
| Longitudinal superior | M > F | Demasculinized | Right |
| Fronto-occipital inferior | M > F | Masculine | |
| Forceps minor | M > F | Demasculinized | Right |
| Cingulum | M > F | Demasculinized | Right |
| Corticospinal tract | M > F | Demasculinized | Right |