Figure 4.

The regulation of rhein on the crosstalk of PI3K-AKT signaling pathway. In this pathway, AKT is the bridge of the extracellular signal and the nuclear gene expression, affecting some of its downstream pathways. The regulation of rhein on these pathways is probably because of the indirect influence of rhein through hub AKT protein mediation or the direct action to the AKT downstream protein. The protein marked with star is the target of rhein. Red and green star represent negative and positive regulation, respectively.