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. 2016 Aug 17;36(33):8712–8725. doi: 10.1523/JNEUROSCI.4118-15.2016

Figure 3.

Figure 3.

Effect of mSYMPX on established pain behaviors in the local DRG inflammation model. Two baseline pain measurements were obtained (plotted on POD −7 and POD 0). On POD 0, the L5 DRG was inflamed. On POD 14, a second surgery was performed to cut the L4 and L5 gray rami (post mSYMPX), or the corresponding sham operation was performed. Behaviors were measured on POD 13 just before and POD 15 just after the second surgery. Post mSYMPX rapidly ameliorated the decreased von Frey threshold (A) and the increased response to light strokes (B). Effects on cold allodynia (C) were less marked. *p < 0.05; ***p < 0.001, significant difference between the two groups at indicated time points (two-way repeated-measures ANOVA with Bonferroni post hoc test). N = 8 male rats per group. Experimenter was blinded starting on POD 14 as to the mSYMPX/Sham status. PWT, Paw withdrawal threshold.