Figure 5.

mSYMPX reduces macrophage staining in the inflamed DRG. DRG sections were obtained from normal animals, or obtained 4 d after DRG inflammation (LID), which was performed 7 d after mSYMPX or sham mSYMPX surgery. Red staining represents macrophage marker Iba-1. A, Example of Iba-1 staining in cellular areas in normal DRG. B, Example of inflamed DRG with prior sham mSYMPX. C, Example of inflamed DRG with prior mSYMPX. D, Summary data of Iba-1 intensity normalized to area of the DRG measured; only areas containing neuronal cell bodies were included in the analysis and examples shown are from cellular areas. **p < 0.01; ***p < 0.001, significant difference between indicated groups (ANOVA with Tukey's post hoc test). The normal and LID + mSYMPX groups did not differ significantly from each other. N = 4 rats per group, equal numbers of male and female rats, 19–28 sections per animal.