Figure 7. Model of epigenome editing to achieve stable gene reactivation depending on the chromatin microenvironment.

(a) Stable gene reactivation is achieved by targeting H3K4 methyltransferases to a non-hypermethylated locus. (b) Gene reactivation is not achieved by targeting H3K4 methyltransferases to a hypermethylated locus. (c) Co-targeting different epigenetic editors to achieve sustained reactivation at hypermethylated locus.