Table 4. The endoplasmic reticulum (ER) stress response-related molecules with significantly altered expression.

Gene symbol	Object type	Description	Integrity biomarker	Signal (fold change)	P value
DDIT3	Transcription factor	DNA damage-inducible transcript 3 protein	DNA damage-inducible transcript 3	7.711006	1.05E−04
HERPUD1	Generic binding protein	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein	6.36406	1.37E−04
PPP1R15A	Generic binding protein	Protein phosphatase 1 regulatory subunit 15A	Protein phosphatase 1 regulatory subunit 15A	4.787228	2.70E−04
HSPA5	Generic binding protein	78 kDa glucose-regulated protein	Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)	3.58693	4.49E−04
EDEM1	Generic enzyme	ER degradation-enhancing alpha-mannosidase-like protein 1	ER degradation-enhancing alpha-mannosidase-like 1	2.713944	1.09E−03
XBP1	Transcription factor	X-box-binding protein 1	X-box-binding protein 1	2.443152	9.49E−05
HSP90B1	Generic binding protein	Endoplasmin	Endoplasmin	2.367735	2.89E−04
NFKBIA	Generic binding protein	–	Nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor, alpha	2.134665	4.07E−04
ATF-4	Transcription factor	Cyclic AMP-dependent transcription factor ATF-4	Cyclic AMP-dependent transcription factor ATF-4	2.045582	7.35E−04

ER stress-responsive molecules, including DNA damage-inducible transcript 3 (DDIT3) and 78 kDa glucose-regulated protein, were significantly upregulated in the ferrichrome-treated cells (n=3).