Table 1.
Comparison of the five measurement systems
| PROMIS® | NIH Toolbox® | Neuro-QoL | ASCQ-Me | PRO-CTCAE | |
|---|---|---|---|---|---|
| Type of Measure | Self-report, proxy-report | Performance-based; self-report, proxy-report | Self-report | Self-report | Self-report |
| Generic or Disease-Specific | Generic | Generic | Neurological conditions | Sickle Cell Disease | Cancer |
| Constructs Measured | Physical, mental, social, and global health domains | Emotion, cognition, sensation, and motor function | Effects of neurological conditions on physical, mental, and social health domains | Effects of Sickle Cell Disease on physical, social, and emotional functioning and well-being | Symptomatic toxicity (companion to CTCAE) |
| Available Instruments | Item banks addressing >75 domains | Item banks and performance-based measures of function organized into four domain batteries (emotion, cognition, sensation, and motor function) | Item banks addressing >20 domains | Item banks addressing >7 domains | 124 items reflecting 78 symptomatic toxicities |
| Formats | Static short forms, computerized adaptive tests (CATs) | Static short forms, CATs | Static short forms, CATs | Static short forms, CATs | Static short forms with conditional branching |
| Mode of Administration | Paper, web, handheld device, interactive voice response system (IVRS) | Paper (for emotion), web, handheld device (for all) | Paper, web, handheld device, IVRS | Paper, web, handheld device, IVRS | Paper, web, IVRS |
| Age | Pediatric and adult | Pediatric, adult, older adult | Pediatric and adult | Adult | Adult; pediatric measure in development |
| Available Languages | >40 (including English and Spanish) | English and Spanish | English and Spanish | English and Spanish | English, Spanish, German, and Japanese |
| Others in development | Others in development | Others in development | Others in development | Others in development | |
| Contexts of Use | Population surveillance, clinical research and trials, care delivery | Epidemiologic studies, clinical research and trials | Population surveillance, clinical research and trials in persons with a neurologic disorder | Population surveillance, clinical research and trials in persons with Sickle Cell Disease | Cancer clinical trials including supportive care trials, clinical studies of cancer patients and survivors |
| For more information | www.HealthMeasures.net | www.HealthMeasures.net | www.HealthMeasures.net | www.HealthMeasures.net | http://healthcaredelivery.cancer.gov/pro-ctcae/ |