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. 2016 Aug 17;6:31534. doi: 10.1038/srep31534

Figure 3. p66Shc increased intracellular ROS, accompanied by an enhanced level of 8-OHdG.

Figure 3

(A) MCF-7 cells were treated with NC, 80 MOI Ad-p66Shc and 160 MOI Ad-p66Shc for 48 h. DCFH-DA staining showed that p66Shc significantly induced intracellular ROS. *p < 0.05, ***p < 0.001 vs Negative control. (B) MCF-7 cells were infected with 100 MOI Ad-p66Shc or negative control for 48 h. The upregulation of p66Shc also increased the level of 8-OHdG. The data represent the means ± SEM, n = 3 independent experiments. **p < 0.01 vs NC (NC: negative control).