Table 2. Cytotoxicity and proliferation of cells treated with JO146.

Koala PBMC LDH Assay - % cytotoxicity (n = 4)α
100 μM JO146§	DMSO
−3.10 ± (3.41)	1.77 ± (3.02)
Koala PBMC MTS Assay - % proliferation (n = 4)α
100 μM JO146	DMSO
19.74 ± (3.041)	0.29 ± (1.23)
Koala Uterine Tissue LDH Assay - % cytotoxicity (n = 2)α
100 μM JO146§	DMSO§
−3.96 ± (3.56)	−8.70 ± (6.17)
Koala Uterine Tissue MTS Assay - % proliferation (n = 2)α
100 μM JO146	DMSO
23.62 ± (0.20)	10.54 ± (1.52)
Koala Conjunctival Tissue LDH Assay - % cytotoxicity (n = 1)α
100 μM JO146§	DMSO
−10.76	−18.69
Koala Conjunctival Tissue MTS Assay - % proliferation (n = 1)α
100 μM JO146	DMSO
3.86	1.03

^αExperiments were performed in triplicate and the results expressed as percentage cell death compared with untreated control cells by using the formula [1 − (mean absorbance of treated cells/mean absorbance of untreated cells)] * 100. Results are shown with SEM indicated in parenthesis.

^§Negative values indicate treated cultures had less cytotoxicity/more proliferation than control.