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. 2016 Aug 17;6:31748. doi: 10.1038/srep31748

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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MOR-GFP-expressing HEK-293 cells were treated with DAMGO and/or ignavine (IGN). DAMGO induced vesicle formation (shown by red arrowheads) in the intracellular space, which represented receptor internalization, 20 min after administration. A concentration of 10 μM ignavine blocked internalization. In contrast, 1 μM ignavine accelerated DAMGO-induced receptor internalization.