Figure 7. Blood glucose levels of ICR mice in the groups of “NaCl” and “Lira in Gel” during the whole experimental period of 10 days.

n = 6 for each group. Here, the oral gavage of glucose in mice was once-daily performed, and the time points 0, 30, 60 min in the horizon coordination denotes the time after oral administration of glucose. “D0” in the legend denotes the day of injecting the Lira gel formulation, “D9” in the legend indicates day 9 after the treatment with the Lira gel formulation. In the group of “NaCl”, the physiological saline solution was injected daily. The hydrogel formulation of Lira was administrated via a single subcutaneous injection during the whole 10 days of in vivo examination. The continuous liberation of Lira from the hydrogel acted significantly the hypoglycemic efficacy within the initial 7 days. Significant differences between the group of “NaCl” and that of “Lira in Gel” are specifically marked: *p < 0.05, **p < 0.01, ***p < 0.001.