Table 5. Antiproliferative activities of some compounds from T. chinensis against human cancer cell lines.
| Compound | IC50 (μM)a |
||||||
|---|---|---|---|---|---|---|---|
| FaDu | Detroit 562 | CNE-1 | CNE-2 | HepG2 | K562 | SPC-A-1 | |
| 3 | 28.6 ± 1.6* | >50.0 | >50.0 | >50.0 | >50.0 | >50.0 | >50.0 |
| 4 | 27.6 ± 3.6*** | >50.0 | >50.0 | >50.0 | 29.7 ± 3.1*** | >50.0 | >50.0 |
| 5 | 41.2 ± 1.8*** | >50.0 | >50.0 | >50.0 | >50.0 | >50.0 | >50.0 |
| 12 | 12.1 ± 1.2 | >50.0 | >50.0 | >50.0 | >50.0 | >50.0 | >50.0 |
| 17 | 20.3 ± 2.1 | 20.2 ± 2.0 | 33.6 ± 0.3*** | 23.6 ± 1.9*** | 28.6 ± 1.0*** | 27.4 ± 0.2*** | 24.8 ± 0.7*** |
| 18 | >50.0 | 39.4 ± 0.7*** | >50.0 | 40.7 ± 3.1*** | 46.5 ± 1.0*** | >50.0 | >50.0 |
| 19 | 61.4 ± 2.5*** | 21.5 ± 1.1*** | 50.9 ± 1.1*** | 29.5 ± 0.9*** | 34.0 ± 0.5*** | 40.2 ± 2.1*** | 39.4 ± 1.0*** |
| 20 | 20.1 ± 0.4 | 20.1 ± 0.6*** | >50.0 | >50.0 | 28.0 ± 0.7*** | >50.0 | >50.0 |
| 21 | 12.7 ± 1.7* | 22.7 ± 0.5** | 17.4 ± 0.5*** | 14.5 ± 1.1** | 14.3 ± 1.5*** | 22.2 ± 0.2*** | 22.2 ± 0.2*** |
| 22 | 20.5 ± 3.4 | 29.1 ± 0.6* | 33.7 ± 0.6*** | >50.0 | 17.7 ± 0.3*** | 33.8 ± 0.1*** | 26.3 ± 1.0*** |
| CISb | 18.1 ± 0.7 | 26.2 ± 1.5 | 10.8 ± 0.4 | 7.9 ± 1.1 | 6.5 ± 0.3 | 13.5 ± 0.8 | 3.8 ± 0.3 |
aValues are presented as means ± SD (n = 3).
bPositive control.
*p < 0.05, **p < 0.01, ***p < 0.001 versus positive control.