Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Aug 17;6:31665. doi: 10.1038/srep31665

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Basic ON- (a) and OFF- (b) states of β-catenin-dependent canonical Wnt signalling. See text for details. (c) A model in which γ-Pcdh-C3 competes with Dvl for binding to Axin1; this interaction stabilizes Axin1 at the membrane, and results in reduced phosphorylation of Lrp6 and decreased Wnt signalling. It remains unclear (dashed lines, question marks) whether γ-Pcdh-C3-bound Axin1 can assemble a functional destruction complex, or precisely how β-catenin is regulated by γ-Pcdh-C3.