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. Author manuscript; available in PMC: 2016 Aug 17.

Published in final edited form as: Toxicol Sci. 2016 Apr 21;152(1):85–98. doi: 10.1093/toxsci/kfw074

FIG. 3 — Expansion of CTLA4⁺ and nT_reg populations during TDI sensitization. Flow cytometric analysis of dLN CTLA4⁺ T_reg frequency (A) and number (B) and nT_reg (Neuropilin-1⁺) frequency (C) and number (D) following TDI sensitization. Bars represent mean (± SE) of 5 mice per group. P values are represented by (0.5% TDI) and asterisks (4% TDI) (P < 0.05). Significance is indicated as follows: P ≤ .05 (*), P < .01 (**), P ≤ .001 (***), and P ≤ .0001 (****) for 4% TDI or P ≤ .05 (^), P ≤ .01 (), P ≤ .001 (), and P ≤ .0001 () for 0.5% TDI. Dermal treatment groups are indicated by the following symbols: circle, acetone; square, 0.5% TDI; and triangle, 4% TDI.

Inline graphic — Expansion of CTLA4⁺ and nT_reg populations during TDI sensitization. Flow cytometric analysis of dLN CTLA4⁺ T_reg frequency (A) and number (B) and nT_reg (Neuropilin-1⁺) frequency (C) and number (D) following TDI sensitization. Bars represent mean (± SE) of 5 mice per group. P values are represented by (0.5% TDI) and asterisks (4% TDI) (P < 0.05). Significance is indicated as follows: P ≤ .05 (*), P < .01 (**), P ≤ .001 (***), and P ≤ .0001 (****) for 4% TDI or P ≤ .05 (^), P ≤ .01 (), P ≤ .001 (), and P ≤ .0001 () for 0.5% TDI. Dermal treatment groups are indicated by the following symbols: circle, acetone; square, 0.5% TDI; and triangle, 4% TDI.