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. 2015 Dec 11;23(6):1038–1048. doi: 10.1038/cdd.2015.157

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Copyright © 2016 Macmillan Publishers Limited

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Cdk12 deficiency results in impaired outgrowth of the blastocyst. (A) Blastocysts were collected by Cdk12^fx/− intercrossing and cultured in vitro for 4 days. At the indicated day, embryos were photographed under bright-field conditions. The surface areas of the ICM (B) and TG (C) outgrowth at daily intervals are showed as mean±S.E.M. *P<0.05, by one-way ANOVA. Cdk12^fx/fx, n=10; Cdk12^fx/−, n=21; Cdk12^−/−, n=8. (D) E3.5 embryos were cultured in vitro for 4 days and then immunostained with anti-Cdk12 and anti-Oct4 antibodies. Nuclei are marked by DAPI staining. Scale bar, 50 μm