Figure 1.

Development of dermatitis in ΔNp63 transgenic mice. (a) Gross morphology showing progression of dermatitis lesions in adult ΔNp63BG mice at various stages as indicated after induction of ΔNp63 transgene expression. (b) Clinical skin severity scores of dermatitis in control (n=15) and transgenic mice (n=15). Quantitative evaluations of clinical scores were based on the criteria described in the Materials and Methods. (c) Spontaneous scratching was counted in wild-type and bi-transgenic mice after 13 weeks of transgene induction for 5 min (n=10). Data are represented as mean±S.D. of three experiments. *P<0.001, Student's t-test. (d) Total serum IgE levels were measured by ELISA (n=6). Data are represented as mean±S.E. *P<0.001, Student's t-test