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PS targeting antibodies selectively target the tumor microenvironment. Localization of near-infrared (NIR)-labeled Bavituximab F(ab)2 to orthotopically implanted PC3 prostate tumor in male SCID mice. Animals were injected with 25 μg NIR-PGN650 (a) or NIR-control IgG F(ab')2 (b). Fluorescent imaging was conducted 24 h following injection of NIR-labeled antibodies. Anti-PS antibodies specifically localize to tumor blood vessels (c)
