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. 2016 Jul 26;113(32):E4716–E4725. doi: 10.1073/pnas.1605737113

Fig. 8.

Fig. 8.

Gipc3 disruption enhances spontaneous SGN firing. (A) Cumulative histogram of spontaneous rate distribution: no major overlap of the data. WT (C57BL/6) data were taken from ref. 19. The spontaneous rate of Gipc3 SGNs showed a shift of mean about 21.5 Hz in comparison with that of WT SGNs. The null hypothesis that the spontaneous discharge rates Gipc3 and WT SGNs came from populations with the same distribution was rejected, and the alternative hypothesis that the cumulative distribution function of WT was larger than that of Gipc3 SGNs was favored (P < 0.05, one-sided Kolmogorov–Smirnov test). (B) Peristimulus time histogram of 3-wk-old Gipc3 and WT SGNs to 50-ms suprathreshold tone bursts at the characteristic frequency. The onset firing rates of Gipc3 were elevated (451.4 ± 27.0 Hz for Gipc3 mutant, 25 SGNs vs. 347.1 ± 26.1 Hz for WT, 24 SGNs, P < 0.05). The steady-state firing rates did not differ significantly (159.5 ± 8.6 Hz for Gipc3 mutant, 25 SGNs vs. 154.3 ± 10.4 Hz for WT, 24 SGNs, not significant by Wilcoxon rank sum test). (C) Rate-intensity functions (Left) and dynamic range (Right) of sound encoding in Gipc3 and WT SGNs. Gipc3 SGNs had a narrower dynamic range than WT SGNs (9.9 ± 0.6 dB for Gipc3 p14–25, 19 SGNs vs. 13.7 ± 1.1 dB for WT p14–21, 20 SGNs, P < 0.01, Wilcoxon rank sum test).