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Crystal structures of Mmα-GluIITryps in complex with iminosugar inhibitors. Structures of complexes of Mmα-GluIITryps with castanospermine (A), DNJ (B), NB-DNJ (C), and MON-DNJ (D). Upon alkylation of the endocyclic nitrogen, the W525 side chain in the NB-DNJ complex is disordered (asterisk in C), whereas the longer chain of MON-DNJ causes complete disordering of the α 525–527 hairpin loop (D). The side chain of MON-DNJ adopts two main conformations, which interact with F307 and F571.
