Fig. 3.

Distinct gene expression profiles were specifically associated with CT and MT at 14 y old or adolescent processes of cortical consolidation. PLS1 identified a profile of genes that were (A) overexpressed in occipital and somatosensory cortices, (B) negatively correlated with baseline CT, and (C) positively correlated with baseline MT. PLS2 identified a profile of genes that were (D) overexpressed in prefrontal cortex, (E) negatively correlated with adolescent cortical shrinkage (ΔCT), and (F) positively correlated with adolescent intracortical myelination (ΔMT). (G) PLS2 was enriched for genes functionally related to synaptic transmission, glutamatergic signaling, and potassium ion channels (color-coded by P value for significant enrichment) in the gene ontology of biological processes.